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== Health == A study conducted in Japan of cats suspected to have kidney problems found that 47% of tested American Shorthair cats had the PKD1 mutation, which is responsible for feline polycystic kidney disease (PKD). A review of over 5,000 cases of urate urolithiasis in the United States found that the American Shorthair had significantly lower odds of developing urate uroliths than mixed-breed cats.
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